| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen phosphorylase, liver form |
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| Ligand | BDBM50174380 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_321698 (CHEMBL872321) |
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| pH | 7.2±n/a |
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| IC50 | 200±n/a nM |
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| Comments | extracted |
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| Citation |  Klabunde, T; Wendt, KU; Kadereit, D; Brachvogel, V; Burger, HJ; Herling, AW; Oikonomakos, NG; Kosmopoulou, MN; Schmoll, D; Sarubbi, E; von Roedern, E; Schönafinger, K; Defossa, E Acyl ureas as human liver glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. J Med Chem48:6178-93 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycogen phosphorylase, liver form |
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| Name: | Glycogen phosphorylase, liver form |
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| Synonyms: | Glycogen Phosphorylase (PYGL) | Glycogen Phosphorylase, liver form | Liver glycogen phosphorylase | PYGL | PYGL_HUMAN |
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| Type: | Homodimer |
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| Mol. Mass.: | 97153.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Dimers associate into a tetramer to form the enzymatically active phosphorylase A. |
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| Residue: | 847 |
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| Sequence: | MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTV
RDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDI
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEA
DDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVN
TMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKL
PWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFP
KDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKF
QNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQ
ENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFV
PRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPA
TDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVA
ALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEA
YVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNE
SNKVNGN
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| BDBM50174380 |
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| n/a |
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| Name | BDBM50174380 |
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| Synonyms: | 4-Chloro-3-[3-(2,4-dichloro-benzoyl)-ureido]-N-methyl-benzamide | CHEMBL194840 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H12Cl3N3O3 |
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| Mol. Mass. | 400.644 |
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| SMILES | CNC(=O)c1ccc(Cl)c(NC(=O)NC(=O)c2ccc(Cl)cc2Cl)c1 |
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| Structure | 
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