| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Phosphatidylinositol 3-kinase catalytic subunit type 3 |
|---|
| Ligand | BDBM50597814 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2224477 (CHEMBL5137990) |
|---|
| IC50 | 48±n/a nM |
|---|
| Citation |  Hu, DX; Patel, S; Chen, H; Wang, S; Staben, ST; Dimitrova, YN; Wallweber, HA; Lee, JY; Chan, GKY; Sneeringer, CJ; Prangley, MS; Moffat, JG; Wu, KC; Schutt, LK; Salphati, L; Pang, J; McNamara, E; Huang, H; Chen, Y; Wang, Y; Zhao, W; Lim, J; Murthy, A; Siu, M Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors. J Med Chem65:11500-11512 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Phosphatidylinositol 3-kinase catalytic subunit type 3 |
|---|
| Name: | Phosphatidylinositol 3-kinase catalytic subunit type 3 |
|---|
| Synonyms: | BC033004 | PI3K type 3 | PIK3C3 | PK3C3_HUMAN | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) | Phosphatidylinositol 3-kinase p100 subunit | Phosphoinositide 3-Kinase (PI3K), Vps34 | Phosphoinositide-3-kinase class 3 | PtdIns-3-kinase type 3 | VPS34 | hVPS34 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 101551.30 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant human Vps34 protein was expressed as monomeric GST-fusion and purified. |
|---|
| Residue: | 887 |
|---|
| Sequence: | MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVT
CQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAV
PVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGRTSSTLSEDQMSRLAKLTK
AHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDG
DESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIV
SYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDV
EDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKK
DSQSSVSENVSNSGINSAEIDSSQIITSPLPSVSSPPPASKTKEVPDGENLEQDLCTFLI
SRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRS
LLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVK
IRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRK
ENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNGISAE
VMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLN
KEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVK
KVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK
|
|
|
|---|
| BDBM50597814 |
|---|
| n/a |
|---|
| Name | BDBM50597814 |
|---|
| Synonyms: | CHEMBL5200373 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H23N5O2 |
|---|
| Mol. Mass. | 353.4182 |
|---|
| SMILES | CC(C)[C@@H]1CNC(=O)c2cc(nn12)-c1cc(NC(=O)C2CC2)ncc1C |r| |
|---|
| Structure | 
|
|---|
Search and Browse
