| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 2 |
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| Ligand | BDBM50597848 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2224679 (CHEMBL5138192) |
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| IC50 | 3530±n/a nM |
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| Citation |  Gu, X; Zhang, H; Jiao, M; Han, B; Zhang, Z; Li, J; Zhang, Q Histone deacetylase 6 inhibitors with blood-brain barrier penetration as a potential strategy for CNS-Disorders therapy. Eur J Med Chem229:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 2 |
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| Name: | Histone deacetylase 2 |
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| Synonyms: | Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2 |
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| Type: | Chromatin regulator; hydrolase; repressor |
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| Mol. Mass.: | 55356.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92769 |
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| Residue: | 488 |
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| Sequence: | MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
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| BDBM50597848 |
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| n/a |
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| Name | BDBM50597848 |
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| Synonyms: | CHEMBL5205841 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H28N6O3 |
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| Mol. Mass. | 436.5068 |
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| SMILES | C[C@@H]1CN(Cc2ccc(cc2)C(=O)NO)C[C@H]1c1nc2n(ncc2c(=O)[nH]1)C1CCCC1 |r| |
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| Structure | 
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