| Reaction Details |
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 | Report a problem with these data |
| Target | Protein arginine N-methyltransferase 1 |
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| Ligand | BDBM50598010 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2225430 (CHEMBL5138943) |
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| IC50 | 1200±n/a nM |
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| Citation |  Iannelli, G; Milite, C; Marechal, N; Cura, V; Bonnefond, L; Troffer-Charlier, N; Feoli, A; Rescigno, D; Wang, Y; Cipriano, A; Viviano, M; Bedford, MT; Cavarelli, J; Castellano, S; Sbardella, G Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach. J Med Chem65:11574-11606 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein arginine N-methyltransferase 1 |
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| Name: | Protein arginine N-methyltransferase 1 |
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| Synonyms: | 2.1.1.319 | ANM1_HUMAN | HMT2 | HRMT1L2 | HRMT1L2 {ECO:0000303|PubMed:11097842 | Histone-arginine N-methyltransferase PRMT1 | IR1B4 | Interferon receptor 1-bound protein 4 | PRMT1 | Protein arginine N-methyltransferase 1 | Protein-arginine N-methyltransferase 1 | Synonyms=HMT2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42451.61 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_100878 |
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| Residue: | 371 |
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| Sequence: | MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHF
GIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECS
SISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYA
RDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVV
DPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTG
FSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLC
ELSCSTDYRMR
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| BDBM50598010 |
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| n/a |
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| Name | BDBM50598010 |
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| Synonyms: | CHEMBL5179077 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H25N5O4 |
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| Mol. Mass. | 387.4329 |
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| SMILES | COC(=O)c1cc(O)c2cc(NC(=O)NCCCCCNC(N)=N)ccc2c1 |
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| Structure | 
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