| Reaction Details |
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 | Report a problem with these data |
| Target | Protein arginine N-methyltransferase 7 |
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| Ligand | BDBM50598016 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2225436 (CHEMBL5138949) |
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| IC50 | 550±n/a nM |
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| Citation |  Iannelli, G; Milite, C; Marechal, N; Cura, V; Bonnefond, L; Troffer-Charlier, N; Feoli, A; Rescigno, D; Wang, Y; Cipriano, A; Viviano, M; Bedford, MT; Cavarelli, J; Castellano, S; Sbardella, G Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach. J Med Chem65:11574-11606 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein arginine N-methyltransferase 7 |
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| Name: | Protein arginine N-methyltransferase 7 |
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| Synonyms: | ANM7_HUMAN | Histone-arginine N-methyltransferase PRMT7 | KIAA1933 | PRMT7 | Protein arginine N-methyltransferase 7 | Protein arginine methyltransferase 7 (PRMT7) | [Myelin basic protein]-arginine N-methyltransferase PRMT7 |
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| Type: | Enzyme |
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| Mol. Mass.: | 78440.77 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NVM4 |
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| Residue: | 692 |
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| Sequence: | MKIFCSRANPTTGSVEWLEEDEHYDYHQEIARSSYADMLHDKDRNVKYYQGIRAAVSRVK
DRGQKALVLDIGTGTGLLSMMAVTAGADFCYAIEVFKPMADAAVKIVEKNGFSDKIKVIN
KHSTEVTVGPEGDMPCRANILVTELFDTELIGEGALPSYEHAHRHLVEENCEAVPHRATV
YAQLVESGRMWSWNKLFPIHVQTSLGEQVIVPPVDVESCPGAPSVCDIQLNQVSPADFTV
LSDVLPMFSIDFSKQVSSSAACHSRRFEPLTSGRAQVVLSWWDIEMDPEGKIKCTMAPFW
AHSDPEEMQWRDHWMQCVYFLPQEEPVVQGSALYLVAHHDDYCVWYSLQRTSPEKNERVR
QMRPVCDCQAHLLWNRPRFGEINDQDRTDRYVQALRTVLKPDSVCLCVSDGSLLSVLAHH
LGVEQVFTVESSAASHKLLRKIFKANHLEDKINIIEKRPELLTNEDLQGRKVSLLLGEPF
FTTSLLPWHNLYFWYVRTAVDQHLGPGAMVMPQAASLHAVVVEFRDLWRIRSPCGDCEGF
DVHIMDDMIKRALDFRESREAEPHPLWEYPCRSLSEPWQILTFDFQQPVPLQPLCAEGTV
ELRRPGQSHAAVLWMEYHLTPECTLSTGLLEPADPEGGCCWNPHCKQAVYFFSPAPDPRA
LLGGPRTVSYAVEFHPDTGDIIMEFRHADTPD
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| BDBM50598016 |
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| n/a |
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| Name | BDBM50598016 |
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| Synonyms: | CHEMBL5170047 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H34N10O7 |
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| Mol. Mass. | 622.6324 |
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| SMILES | COC(=O)c1cc(O)c2cc(NC(=O)NCCCCNC(=N)NC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c(N)ncnc34)ccc2c1 |r| |
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| Structure | 
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