Ki Summary

Reaction Details

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Target

Melanocortin receptor 4

Ligand

BDBM50174863

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_326975 (CHEMBL868738)

EC50

1±n/a nM

Citation

Cheung, AW; Qi, L; Gore, V; Chu, XJ; Bartkovitz, D; Kurylko, G; Swistok, J; Danho, W; Chen, L; Yagaloff, K Preparation of human Melanocortin-4 receptor agonist libraries: linear peptides X-Y-DPhe7-Arg8-Trp(or 2-Nal)9-Z-NH2. Bioorg Med Chem Lett15:5504-8 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocortin receptor 4

Name:

Melanocortin receptor 4

Synonyms:

Type:

Enzyme

Mol. Mass.:

36949.50

Organism:

Homo sapiens (Human)

Description:

P32245

Residue:

332

Sequence:

MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY

BDBM50174863

n/a

Name

BDBM50174863

Synonyms:

CHEMBL411817 | X3-Apc-DPhe-Arg-Trp-Z10-NH2

Type

Small organic molecule

Emp. Form.

C55H62N10O6

Mol. Mass.

959.1442

SMILES

NC(N)=NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@]1(CC[C@@H](CC1)c1ccccc1)NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(cc1)C(N)=O |wU:7.7,25.29,11.19,22.36,wD:47.50,22.22,(13.13,-24.28,;11.79,-25.06,;10.45,-24.28,;11.79,-26.6,;10.45,-27.37,;10.45,-28.92,;9.11,-29.69,;9.11,-31.24,;7.77,-32.01,;6.43,-31.24,;6.43,-29.69,;5.1,-32.01,;5.1,-33.55,;6.43,-34.33,;6.42,-35.88,;7.76,-36.65,;9.1,-35.88,;9.1,-34.32,;7.76,-33.55,;3.76,-31.24,;2.42,-32.01,;2.42,-33.55,;1.09,-31.24,;2.42,-30.47,;2.42,-28.94,;1.1,-28.17,;-.24,-28.93,;-.25,-30.47,;1.1,-26.63,;2.44,-25.87,;2.45,-24.33,;1.12,-23.56,;-.22,-24.33,;-.22,-25.86,;-.26,-32.01,;-1.6,-31.24,;-1.6,-29.69,;-2.93,-32.01,;-4.26,-31.24,;-4.26,-29.71,;-5.59,-28.94,;-6.92,-29.71,;-6.91,-31.26,;-5.58,-32.02,;10.45,-32.01,;10.45,-33.55,;11.79,-31.24,;13.13,-32.01,;13.13,-33.55,;14.47,-34.33,;15.81,-33.55,;16.92,-34.85,;16.15,-36.19,;16.62,-37.65,;15.59,-38.8,;14.08,-38.48,;13.6,-37.01,;14.64,-35.86,;14.47,-31.24,;14.47,-29.69,;15.81,-32.01,;17.14,-31.24,;18.47,-32,;18.47,-33.54,;19.8,-34.31,;21.13,-33.53,;21.12,-31.99,;19.79,-31.23,;22.47,-34.3,;23.79,-33.52,;22.47,-35.84,)|

Structure