Ki Summary

Reaction Details

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Target

Melanocortin receptor 4

Ligand

BDBM50174880

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_326975 (CHEMBL868738)

EC50

50±n/a nM

Citation

Cheung, AW; Qi, L; Gore, V; Chu, XJ; Bartkovitz, D; Kurylko, G; Swistok, J; Danho, W; Chen, L; Yagaloff, K Preparation of human Melanocortin-4 receptor agonist libraries: linear peptides X-Y-DPhe7-Arg8-Trp(or 2-Nal)9-Z-NH2. Bioorg Med Chem Lett15:5504-8 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocortin receptor 4

Name:

Melanocortin receptor 4

Synonyms:

Type:

Enzyme

Mol. Mass.:

36949.50

Organism:

Homo sapiens (Human)

Description:

P32245

Residue:

332

Sequence:

MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY

BDBM50174880

n/a

Name

BDBM50174880

Synonyms:

CHEMBL199740 | Penta-Apc-DPhe-Arg-2-Nal-Gly-NH2

Type

Small organic molecule

Emp. Form.

C48H61N9O6

Mol. Mass.

860.0546

SMILES

CCCCC(=O)N[C@@]1(CC[C@@H](CC1)c1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC(Cc1ccc2ccccc2c1)C(=O)NCC(N)=O |wU:22.23,33.35,7.6,10.13,wD:7.20,(-4.4,-.98,;-3.07,-1.75,;-1.73,-.99,;-.4,-1.76,;.93,-.99,;.93,.55,;2.27,-1.76,;3.61,-.99,;4.94,-.23,;4.94,1.3,;3.62,2.08,;2.28,1.31,;2.28,-.22,;3.63,3.61,;4.96,4.38,;4.98,5.91,;3.65,6.69,;2.31,5.92,;2.31,4.38,;4.94,-1.76,;4.94,-3.3,;6.29,-.99,;7.62,-1.76,;7.62,-3.3,;8.95,-4.07,;8.95,-5.63,;10.28,-6.39,;11.62,-5.63,;11.61,-4.07,;10.28,-3.3,;8.95,-.99,;8.95,.55,;10.29,-1.76,;11.63,-.99,;11.63,.55,;12.97,1.33,;12.97,2.88,;14.3,3.64,;14.3,5.19,;15.65,5.96,;12.97,5.96,;12.97,-1.76,;12.97,-3.3,;14.3,-.99,;15.65,-1.76,;15.65,-3.3,;16.98,-4.07,;18.31,-3.31,;19.65,-4.08,;19.65,-5.63,;20.98,-6.4,;20.97,-7.95,;19.63,-8.72,;18.29,-7.94,;18.3,-6.4,;16.97,-5.62,;16.98,-.99,;16.98,.55,;18.31,-1.76,;19.65,-.99,;20.97,-1.75,;22.31,-.98,;20.98,-3.28,)|

Structure