Ki Summary

Reaction Details

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Target

Melanocortin receptor 4

Ligand

BDBM50174882

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_326975 (CHEMBL868738)

EC50

2±n/a nM

Citation

Cheung, AW; Qi, L; Gore, V; Chu, XJ; Bartkovitz, D; Kurylko, G; Swistok, J; Danho, W; Chen, L; Yagaloff, K Preparation of human Melanocortin-4 receptor agonist libraries: linear peptides X-Y-DPhe7-Arg8-Trp(or 2-Nal)9-Z-NH2. Bioorg Med Chem Lett15:5504-8 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocortin receptor 4

Name:

Melanocortin receptor 4

Synonyms:

Type:

Enzyme

Mol. Mass.:

36949.50

Organism:

Homo sapiens (Human)

Description:

P32245

Residue:

332

Sequence:

MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY

BDBM50174882

n/a

Name

BDBM50174882

Synonyms:

CHEMBL425992 | X2-Apc-DPhe-Arg-Trp-Z8-NH2

Type

Small organic molecule

Emp. Form.

C52H65N11O6

Mol. Mass.

940.1426

SMILES

CCCCNC(=O)N[C@@]1(CC[C@@H](CC1)c1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(c1)C(N)=O |wU:34.36,11.14,23.24,8.7,wD:45.47,8.21,(-3.3,-35.98,;-1.97,-35.21,;-.64,-35.98,;.69,-35.21,;2.02,-35.98,;3.35,-35.21,;3.35,-33.66,;4.69,-35.98,;6.03,-35.21,;7.36,-34.44,;7.37,-32.91,;6.04,-32.14,;4.71,-32.9,;4.7,-34.44,;6.05,-30.61,;7.38,-29.85,;7.39,-28.31,;6.06,-27.54,;4.72,-28.31,;4.72,-29.84,;7.36,-35.98,;7.36,-37.52,;8.7,-35.21,;10.04,-35.98,;10.04,-37.52,;11.37,-38.3,;11.36,-39.84,;12.7,-40.61,;14.04,-39.84,;14.03,-38.29,;12.69,-37.52,;11.37,-35.21,;11.37,-33.66,;12.71,-35.98,;14.04,-35.21,;14.04,-33.66,;15.38,-32.89,;15.38,-31.34,;16.72,-30.58,;16.72,-29.03,;18.06,-28.26,;15.38,-28.26,;15.38,-35.98,;15.38,-37.52,;16.72,-35.21,;18.06,-35.98,;18.06,-37.52,;19.4,-38.3,;20.74,-37.51,;21.84,-38.81,;21.08,-40.15,;21.55,-41.61,;20.52,-42.76,;19,-42.44,;18.53,-40.97,;19.57,-39.82,;19.4,-35.21,;19.4,-33.66,;20.74,-35.98,;22.06,-35.2,;23.4,-35.97,;23.39,-37.51,;24.72,-38.27,;26.05,-37.5,;26.04,-35.95,;24.71,-35.2,;27.37,-35.18,;28.7,-35.94,;27.36,-33.64,)|

Structure