| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase kinase 1 |
|---|
| Ligand | BDBM50598496 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2227127 (CHEMBL5140640) |
|---|
| IC50 | 2.8±n/a nM |
|---|
| Citation |  Zhu, Q; Chen, N; Tian, X; Zhou, Y; You, Q; Xu, X Hematopoietic Progenitor Kinase 1 in Tumor Immunology: A Medicinal Chemistry Perspective. J Med Chem65:8065-8090 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase kinase kinase kinase 1 |
|---|
| Name: | Mitogen-activated protein kinase kinase kinase kinase 1 |
|---|
| Synonyms: | HPK1 | M4K1_HUMAN | MAP4K1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 91316.07 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_586597 |
|---|
| Residue: | 833 |
|---|
| Sequence: | MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ
KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE
VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA
PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK
GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI
GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP
PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL
SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK
RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS
RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK
IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF
ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM
VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ
LLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
|
|
|
|---|
| BDBM50598496 |
|---|
| n/a |
|---|
| Name | BDBM50598496 |
|---|
| Synonyms: | CHEMBL5206877 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H26FN5O |
|---|
| Mol. Mass. | 479.548 |
|---|
| SMILES | CN1CCc2c(C)cc(cc2C1)-c1cnc(N)c(OCc2ccnc(c2)C#Cc2cccc(F)c2)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
