Ki Summary

Reaction Details

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Target

Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

Ligand

BDBM50598834

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2228087 (CHEMBL5141600)

IC50

4.0±n/a nM

Citation

Szychowski, J; Papp, R; Dietrich, E; Liu, B; Vall�e, F; Leclaire, ME; Fourtounis, J; Martino, G; Perryman, AL; Pau, V; Yin, SY; Mader, P; Roulston, A; Truchon, JF; Marshall, CG; Diallo, M; Duffy, NM; Stocco, R; Godbout, C; Bonneau-Fortin, A; Kryczka, R; Bhaskaran, V; Mao, D; Orlicky, S; Beaulieu, P; Turcotte, P; Kurinov, I; Sicheri, F; Mamane, Y; Gallant, M; Black, WC Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306. J Med Chem65:10251-10284 (2022) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

Name:

Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

Synonyms:

MYT1 | PKMYT1 | PMYT1_HUMAN | Tyrosine- and threonine-specific cdc2-inhibitory kinase

Type:

PROTEIN

Mol. Mass.:

54523.76

Organism:

Homo sapiens (Human)

Description:

ChEMBL_587209

Residue:

499

Sequence:

MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGS
IPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGS
YGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEG
GILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIF
LGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVA
CNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLR
QPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCS
LLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSF
PSFEPRNLLSLFEDTLDPT

BDBM50598834

n/a

Name

BDBM50598834

Synonyms:

CHEMBL5198360

Type

Small organic molecule

Emp. Form.

C20H16N6O2

Mol. Mass.

372.38

SMILES

Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2nc3cccc(C#N)c3nc12 |(2.67,-3.29,;2.96,-2.09,;4.44,-1.66,;4.8,-.16,;3.69,.9,;3.98,2.1,;2.21,.47,;1.32,1.32,;1.85,-1.03,;.34,-1.35,;-.28,-2.76,;.33,-3.83,;-1.81,-2.6,;-2.84,-3.74,;-4.05,-3.49,;-2.46,-4.91,;-2.13,-1.09,;-3.47,-.32,;-3.47,1.22,;-4.8,1.99,;-4.8,3.53,;-3.47,4.3,;-2.13,3.53,;-.8,4.3,;.27,4.91,;-2.13,1.99,;-.8,1.22,;-.8,-.32,)|

Structure