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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase | ||
| Ligand | BDBM50598835 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2228087 (CHEMBL5141600) | ||
| IC50 | <3.0±n/a nM | ||
| Citation |  Szychowski, J; Papp, R; Dietrich, E; Liu, B; Vallée, F; Leclaire, ME; Fourtounis, J; Martino, G; Perryman, AL; Pau, V; Yin, SY; Mader, P; Roulston, A; Truchon, JF; Marshall, CG; Diallo, M; Duffy, NM; Stocco, R; Godbout, C; Bonneau-Fortin, A; Kryczka, R; Bhaskaran, V; Mao, D; Orlicky, S; Beaulieu, P; Turcotte, P; Kurinov, I; Sicheri, F; Mamane, Y; Gallant, M; Black, WC Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306. J Med Chem65:10251-10284 (2022) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase | |||
| Name: | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase | ||
| Synonyms: | MYT1 | PKMYT1 | PMYT1_HUMAN | Tyrosine- and threonine-specific cdc2-inhibitory kinase | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 54523.76 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_587209 | ||
| Residue: | 499 | ||
| Sequence: |
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| BDBM50598835 | |||
| n/a | |||
| Name | BDBM50598835 | ||
| Synonyms: | CHEMBL5169345 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H21N7O2 | ||
| Mol. Mass. | 427.4585 | ||
| SMILES | Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2nc3cccc(-c4ccnn4C)c3nc12 |(2.67,-4.15,;2.96,-2.95,;4.44,-2.52,;4.8,-1.03,;3.69,.04,;3.98,1.24,;2.21,-.39,;1.32,.45,;1.85,-1.89,;.34,-2.21,;-.28,-3.62,;.33,-4.69,;-1.81,-3.46,;-2.84,-4.61,;-4.05,-4.35,;-2.46,-5.78,;-2.13,-1.95,;-3.47,-1.18,;-3.47,.36,;-4.8,1.13,;-4.8,2.67,;-3.47,3.44,;-2.13,2.67,;-.8,3.44,;.59,2.8,;1.62,3.94,;.85,5.27,;-.66,4.96,;-1.58,5.78,;-2.13,1.13,;-.8,.36,;-.8,-1.18,)| | ||
| Structure | 
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