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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase | ||
| Ligand | BDBM50598839 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2228087 (CHEMBL5141600) | ||
| IC50 | 5.0±n/a nM | ||
| Citation |  Szychowski, J; Papp, R; Dietrich, E; Liu, B; Vallée, F; Leclaire, ME; Fourtounis, J; Martino, G; Perryman, AL; Pau, V; Yin, SY; Mader, P; Roulston, A; Truchon, JF; Marshall, CG; Diallo, M; Duffy, NM; Stocco, R; Godbout, C; Bonneau-Fortin, A; Kryczka, R; Bhaskaran, V; Mao, D; Orlicky, S; Beaulieu, P; Turcotte, P; Kurinov, I; Sicheri, F; Mamane, Y; Gallant, M; Black, WC Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306. J Med Chem65:10251-10284 (2022) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase | |||
| Name: | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase | ||
| Synonyms: | MYT1 | PKMYT1 | PMYT1_HUMAN | Tyrosine- and threonine-specific cdc2-inhibitory kinase | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 54523.76 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_587209 | ||
| Residue: | 499 | ||
| Sequence: |
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| BDBM50598839 | |||
| n/a | |||
| Name | BDBM50598839 | ||
| Synonyms: | CHEMBL5184178 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H23N5O2 | ||
| Mol. Mass. | 413.4717 | ||
| SMILES | Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2nc3cc(ccc3nc12)C1=CCCC1 |t:30,(4.54,-3.9,;4.84,-2.71,;6.31,-2.27,;6.68,-.78,;5.56,.29,;5.86,1.48,;4.09,-.15,;3.19,.7,;3.73,-1.64,;2.22,-1.97,;1.59,-3.37,;2.21,-4.44,;.06,-3.21,;-.97,-4.36,;-2.17,-4.1,;-.58,-5.53,;-.26,-1.71,;-1.59,-.94,;-1.59,.6,;-2.93,1.37,;-2.93,2.91,;-1.59,3.68,;-.26,2.91,;-.26,1.37,;1.07,.6,;1.07,-.94,;-4.26,3.68,;-5.65,3.05,;-6.68,4.2,;-5.91,5.53,;-4.4,5.21,)| | ||
| Structure | 
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