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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase | ||
| Ligand | BDBM50598841 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2228087 (CHEMBL5141600) | ||
| IC50 | 6.0±n/a nM | ||
| Citation |  Szychowski, J; Papp, R; Dietrich, E; Liu, B; Vallée, F; Leclaire, ME; Fourtounis, J; Martino, G; Perryman, AL; Pau, V; Yin, SY; Mader, P; Roulston, A; Truchon, JF; Marshall, CG; Diallo, M; Duffy, NM; Stocco, R; Godbout, C; Bonneau-Fortin, A; Kryczka, R; Bhaskaran, V; Mao, D; Orlicky, S; Beaulieu, P; Turcotte, P; Kurinov, I; Sicheri, F; Mamane, Y; Gallant, M; Black, WC Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306. J Med Chem65:10251-10284 (2022) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase | |||
| Name: | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase | ||
| Synonyms: | MYT1 | PKMYT1 | PMYT1_HUMAN | Tyrosine- and threonine-specific cdc2-inhibitory kinase | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 54523.76 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_587209 | ||
| Residue: | 499 | ||
| Sequence: |
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| BDBM50598841 | |||
| n/a | |||
| Name | BDBM50598841 | ||
| Synonyms: | CHEMBL5196095 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H21N7O2 | ||
| Mol. Mass. | 427.4585 | ||
| SMILES | Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2nc3c(cccc3nc12)-c1ccnn1C |(4.54,-2.98,;4.84,-1.78,;6.31,-1.35,;6.68,.14,;5.56,1.21,;5.86,2.41,;4.09,.78,;3.19,1.63,;3.73,-.72,;2.22,-1.04,;1.59,-2.45,;2.21,-3.52,;.06,-2.29,;-.97,-3.43,;-2.17,-3.18,;-.58,-4.61,;-.26,-.78,;-1.59,-.01,;-1.59,1.53,;-2.93,2.3,;-2.93,3.84,;-1.59,4.61,;-.26,3.84,;-.26,2.3,;1.08,1.53,;1.08,-.01,;-4.26,1.53,;-5.65,2.17,;-6.68,1.02,;-5.91,-.31,;-4.4,.01,;-3.48,-.81,)| | ||
| Structure | 
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