Ki Summary

Reaction Details

Report a problem with these data

Target

Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

Ligand

BDBM50598849

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2228094 (CHEMBL5141607)

IC50

34±n/a nM

Citation

Szychowski, J; Papp, R; Dietrich, E; Liu, B; Vall�e, F; Leclaire, ME; Fourtounis, J; Martino, G; Perryman, AL; Pau, V; Yin, SY; Mader, P; Roulston, A; Truchon, JF; Marshall, CG; Diallo, M; Duffy, NM; Stocco, R; Godbout, C; Bonneau-Fortin, A; Kryczka, R; Bhaskaran, V; Mao, D; Orlicky, S; Beaulieu, P; Turcotte, P; Kurinov, I; Sicheri, F; Mamane, Y; Gallant, M; Black, WC Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306. J Med Chem65:10251-10284 (2022) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

Name:

Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

Synonyms:

MYT1 | PKMYT1 | PMYT1_HUMAN | Tyrosine- and threonine-specific cdc2-inhibitory kinase

Type:

PROTEIN

Mol. Mass.:

54523.76

Organism:

Homo sapiens (Human)

Description:

ChEMBL_587209

Residue:

499

Sequence:

MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGS
IPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGS
YGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEG
GILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIF
LGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVA
CNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLR
QPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCS
LLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSF
PSFEPRNLLSLFEDTLDPT

BDBM50598849

n/a

Name

BDBM50598849

Synonyms:

CHEMBL5204520

Type

Small organic molecule

Emp. Form.

C18H16N6O2S

Mol. Mass.

380.424

SMILES

Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2nc(cnc12)-c1nccs1 |(3.88,-2.75,;4.17,-1.55,;5.65,-1.12,;6.01,.38,;4.9,1.44,;5.19,2.64,;3.42,1.01,;2.53,1.86,;3.06,-.49,;1.55,-.81,;.93,-2.21,;1.54,-3.28,;-.61,-2.05,;-1.63,-3.2,;-2.84,-2.94,;-1.25,-4.37,;-.92,-.55,;-2.26,.22,;-2.26,1.76,;-.92,2.53,;.41,1.76,;.41,.22,;-3.59,2.53,;-3.74,4.05,;-5.24,4.37,;-6.01,3.04,;-4.98,1.89,)|

Structure