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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase | ||
| Ligand | BDBM50598851 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2228095 (CHEMBL5141608) | ||
| IC50 | 2.0±n/a nM | ||
| Citation |  Szychowski, J; Papp, R; Dietrich, E; Liu, B; Vallée, F; Leclaire, ME; Fourtounis, J; Martino, G; Perryman, AL; Pau, V; Yin, SY; Mader, P; Roulston, A; Truchon, JF; Marshall, CG; Diallo, M; Duffy, NM; Stocco, R; Godbout, C; Bonneau-Fortin, A; Kryczka, R; Bhaskaran, V; Mao, D; Orlicky, S; Beaulieu, P; Turcotte, P; Kurinov, I; Sicheri, F; Mamane, Y; Gallant, M; Black, WC Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306. J Med Chem65:10251-10284 (2022) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase | |||
| Name: | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase | ||
| Synonyms: | MYT1 | PKMYT1 | PMYT1_HUMAN | Tyrosine- and threonine-specific cdc2-inhibitory kinase | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 54523.76 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_587209 | ||
| Residue: | 499 | ||
| Sequence: |
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| BDBM50598851 | |||
| n/a | |||
| Name | BDBM50598851 | ||
| Synonyms: | CHEMBL5199076 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H20N4O2 | ||
| Mol. Mass. | 324.377 | ||
| SMILES | Cc1cc2c(C(N)=O)c(N)n(-c3c(C)ccc(O)c3C)c2nc1C |(-4.93,2.68,;-3.87,2.07,;-3.87,.52,;-2.53,-.25,;-2.21,-1.75,;-3.24,-2.9,;-4.44,-2.64,;-2.86,-4.07,;-.68,-1.91,;-.06,-2.98,;-.05,-.5,;1.45,-.18,;1.81,1.31,;.92,2.16,;3.29,1.75,;4.41,.68,;4.04,-.81,;4.93,-1.66,;2.56,-1.25,;2.27,-2.44,;-1.2,.52,;-1.2,2.07,;-2.53,2.84,;-2.53,4.07,)| | ||
| Structure | 
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