| Reaction Details |
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 | Report a problem with these data |
| Target | RNA demethylase ALKBH5 |
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| Ligand | BDBM50599010 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2228865 (CHEMBL5142378) |
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| IC50 | 19500±n/a nM |
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| Citation |  Huff, S; Kummetha, IR; Zhang, L; Wang, L; Bray, W; Yin, J; Kelley, V; Wang, Y; Rana, TM Rational Design and Optimization of m J Med Chem65:10920-10937 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RNA demethylase ALKBH5 |
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| Name: | RNA demethylase ALKBH5 |
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| Synonyms: | 1.14.11.53 | ABH5 | ALKB5_HUMAN | ALKBH5 | Alkylated DNA repair protein alkB homolog 5 | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5 | OFOXD1 | RNA demethylase ALKBH5 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 44270.53 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_109901 |
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| Residue: | 394 |
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| Sequence: | MAAASGYTDLREKLKSMTSRDNYKAGSREAAAAAAAAVAAAAAAAAAAEPYPVSGAKRKY
QEDSDPERSDYEEQQLQKEEEARKVKSGIRQMRLFSQDECAKIEARIDEVVSRAEKGLYN
EHTVDRAPLRNKYFFGEGYTYGAQLQKRGPGQERLYPPGDVDEIPEWVHQLVIQKLVEHR
VIPEGFVNSAVINDYQPGGCIVSHVDPIHIFERPIVSVSFFSDSALCFGCKFQFKPIRVS
EPVLSLPVRRGSVTVLSGYAADEITHCIRPQDIKERRAVIILRKTRLDAPRLETKSLSSS
VLPPSYASDRLSGNNRDPALKPKRSHRKADPDAAHRPRILEMDKEENRRSVLLPTHRRRG
SFSSENYWRKSYESSEDCSEAAGSPARKVKMRRH
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| BDBM50599010 |
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| n/a |
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| Name | BDBM50599010 |
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| Synonyms: | CHEMBL5196700 | US20230322715, Compound TR-FTO-02 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H21F3N2O |
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| Mol. Mass. | 314.3459 |
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| SMILES | FC(F)(F)c1cccc(CNCC2(COC2)N2CCCC2)c1 |
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| Structure | 
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