Reaction Details |
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Target | Alpha-ketoglutarate-dependent dioxygenase FTO |
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Ligand | BDBM50599015 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2228866 (CHEMBL5142379) |
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IC50 | 870±n/a nM |
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Citation | Huff, S; Kummetha, IR; Zhang, L; Wang, L; Bray, W; Yin, J; Kelley, V; Wang, Y; Rana, TM Rational Design and Optimization of m J Med Chem65:10920-10937 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Alpha-ketoglutarate-dependent dioxygenase FTO |
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Name: | Alpha-ketoglutarate-dependent dioxygenase FTO |
Synonyms: | FTO | FTO_HUMAN | Fat mass and obesity-associated protein | KIAA1752 |
Type: | PROTEIN |
Mol. Mass.: | 58263.75 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1515854 |
Residue: | 505 |
Sequence: | MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEE
LHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPV
KGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVG
MGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRS
AVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDD
LNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFE
PAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHE
VKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDD
ASMPLPFDLTDIVSELRGQLLEAKP
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BDBM50599015 |
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n/a |
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Name | BDBM50599015 |
Synonyms: | CHEMBL5177222 | US20230322715, Compound TR-FTO-14 |
Type | Small organic molecule |
Emp. Form. | C18H25N3O2 |
Mol. Mass. | 315.41 |
SMILES | COc1cccc2c(CNCC3(COC3)N3CCCC3)c[nH]c12 |
Structure |
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