| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium/glucose cotransporter 2 |
|---|
| Ligand | BDBM50179684 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_339094 (CHEMBL869552) |
|---|
| IC50 | 99±n/a nM |
|---|
| Citation |  Zhang, X; Urbanski, M; Patel, M; Cox, GG; Zeck, RE; Bian, H; Conway, BR; Beavers, MP; Rybczynski, PJ; Demarest, KT Indole-glucosides as novel sodium glucose co-transporter 2 (SGLT2) inhibitors. Part 2. Bioorg Med Chem Lett16:1696-701 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium/glucose cotransporter 2 |
|---|
| Name: | Sodium/glucose cotransporter 2 |
|---|
| Synonyms: | Na(+)/glucose cotransporter 2 | SC5A2_HUMAN | SGLT2 | SLC5A2 | Sodium-Dependent Glucose Cotransporter 2 (SGLT2) | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 72902.00 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P31639 |
|---|
| Residue: | 672 |
|---|
| Sequence: | MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGR
SMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTA
GVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIA
LLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSL
TVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQR
CLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVG
CSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDR
ELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRV
NEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLL
TLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQ
APAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLM
MAVAVFLWGFYA
|
|
|
|---|
| BDBM50179684 |
|---|
| n/a |
|---|
| Name | BDBM50179684 |
|---|
| Synonyms: | (2S,3R,4S,5S,6R)-2-(3-(3-fluoro-4-methylbenzyl)-1H-indol-4-yloxy)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol | CHEMBL205459 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H24FNO6 |
|---|
| Mol. Mass. | 417.4275 |
|---|
| SMILES | Cc1ccc(Cc2c[nH]c3cccc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c23)cc1F |
|---|
| Structure | 
|
|---|
Search and Browse
