| Reaction Details |
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 | Report a problem with these data |
| Target | Pteridine reductase 1 |
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| Ligand | BDBM50600683 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2234682 (CHEMBL5148454) |
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| IC50 | 20±n/a nM |
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| Citation |  Pöhner, I; Quotadamo, A; Panecka-Hofman, J; Luciani, R; Santucci, M; Linciano, P; Landi, G; Di Pisa, F; Dello Iacono, L; Pozzi, C; Mangani, S; Gul, S; Witt, G; Ellinger, B; Kuzikov, M; Santarem, N; Cordeiro-da-Silva, A; Costi, MP; Venturelli, A; Wade, RC Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1. J Med Chem65:9011-9033 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Pteridine reductase 1 |
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| Name: | Pteridine reductase 1 |
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| Synonyms: | HMTXR | PTR1 | PTR1_LEIMA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30459.34 |
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| Organism: | Leishmania major |
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| Description: | ChEMBL_1470027 |
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| Residue: | 288 |
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| Sequence: | MTAPTVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAI
TVQADLSNVATAPVSGADGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLR
NDEDGHEPCVGDREAMETATADLFGSNAIAPYFLIKAFAHRFAGTPAKHRGTNYSIINMV
DAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVWEG
HRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA
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| BDBM50600683 |
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| n/a |
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| Name | BDBM50600683 |
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| Synonyms: | CHEMBL5184936 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H30N8O3 |
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| Mol. Mass. | 526.5896 |
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| SMILES | COC(=O)C1CCN(CC1)C(=O)c1ccc(cc1)N(Cc1ccccc1)Cc1cnc2nc(N)nc(N)c2n1 |
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| Structure | 
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