| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Pteridine reductase 1 |
|---|
| Ligand | BDBM50600704 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2234682 (CHEMBL5148454) |
|---|
| IC50 | 150±n/a nM |
|---|
| Citation |  Pöhner, I; Quotadamo, A; Panecka-Hofman, J; Luciani, R; Santucci, M; Linciano, P; Landi, G; Di Pisa, F; Dello Iacono, L; Pozzi, C; Mangani, S; Gul, S; Witt, G; Ellinger, B; Kuzikov, M; Santarem, N; Cordeiro-da-Silva, A; Costi, MP; Venturelli, A; Wade, RC Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1. J Med Chem65:9011-9033 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Pteridine reductase 1 |
|---|
| Name: | Pteridine reductase 1 |
|---|
| Synonyms: | HMTXR | PTR1 | PTR1_LEIMA |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 30459.34 |
|---|
| Organism: | Leishmania major |
|---|
| Description: | ChEMBL_1470027 |
|---|
| Residue: | 288 |
|---|
| Sequence: | MTAPTVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAI
TVQADLSNVATAPVSGADGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLR
NDEDGHEPCVGDREAMETATADLFGSNAIAPYFLIKAFAHRFAGTPAKHRGTNYSIINMV
DAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVWEG
HRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA
|
|
|
|---|
| BDBM50600704 |
|---|
| n/a |
|---|
| Name | BDBM50600704 |
|---|
| Synonyms: | CHEMBL5193762 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H27N7O2 |
|---|
| Mol. Mass. | 493.5597 |
|---|
| SMILES | COc1ccc(Oc2ccc(CN(Cc3ccccc3)Cc3cnc4nc(N)nc(N)c4n3)cc2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
