Ki Summary

Reaction Details

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Target

Toll-like receptor 1

Ligand

BDBM50600882

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2235376 (CHEMBL5149148)

EC50

0.270000±n/a nM

Citation

Yang, MH; Russell, JL; Mifune, Y; Wang, Y; Shi, H; Moresco, EMY; Siegwart, DJ; Beutler, B; Boger, DL Next-Generation Diprovocims with Potent Human and Murine TLR1/TLR2 Agonist Activity That Activate the Innate and Adaptive Immune Response. J Med Chem65:9230-9252 (2022) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Toll-like receptor 1

Name:

Toll-like receptor 1

Synonyms:

Type:

PROTEIN

Mol. Mass.:

90298.92

Organism:

Homo sapiens

Description:

ChEMBL_117187

Residue:

786

Sequence:

MTSIFHFAIIFMLILQIRIQLSEESEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISEL
WTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKISCHPTVNLKHLD
LSFNAFDALPICKEFGNMSQLKFLGLSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKED
PEGLQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKL
QTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLK
ALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLL
TDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCS
WTKSLLSLNMSSNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSL
TDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELGEFVKNID
QVSSEVLEGWPDSYKCDYPESYRGTLLKDFHMSELSCNITLLIVTIVATMLVLAVTVTSL
CSYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLE
KEGMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFH
EGSNSLILILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAINIKL
TEQAKK

BDBM50600882

n/a

Name

BDBM50600882

Synonyms:

CHEMBL5180856

Type

Small organic molecule

Emp. Form.

C64H76Cl3N7O10

Mol. Mass.

1209.688

SMILES

ClC(Cl)(Cl)COC(=O)NCC(=O)OCCCCCCCCCCCCNC(=O)[C@@H]1CN(C[C@H]1C(=O)N[C@H]1C[C@@H]1c1ccccc1)C(=O)c1ccc(cc1)C(=O)N1C[C@H]([C@@H](C1)C(=O)N[C@H]1C[C@@H]1c1ccccc1)C(=O)N[C@H]1C[C@@H]1c1ccccc1 |r|

Structure