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TargetToll-like receptor 1
LigandBDBM50600882
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2235376 (CHEMBL5149148)
EC50 0.270000±n/a nM
Citation Yang, MHRussell, JLMifune, YWang, YShi, HMoresco, EMYSiegwart, DJBeutler, BBoger, DL Next-Generation Diprovocims with Potent Human and Murine TLR1/TLR2 Agonist Activity That Activate the Innate and Adaptive Immune Response. J Med Chem65:9230-9252 (2022) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Toll-like receptor 1
Name:Toll-like receptor 1
Synonyms:CD_antigen=CD281 | KIAA0012 | TIL | TLR1 | TLR1_HUMAN | Toll-like receptor 1 | Toll/interleukin-1 receptor-like protein
Type:PROTEIN
Mol. Mass.:90298.92
Organism:Homo sapiens
Description:ChEMBL_117187
Residue:786
Sequence:
MTSIFHFAIIFMLILQIRIQLSEESEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISEL
WTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKISCHPTVNLKHLD
LSFNAFDALPICKEFGNMSQLKFLGLSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKED
PEGLQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKL
QTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLK
ALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLL
TDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCS
WTKSLLSLNMSSNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSL
TDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELGEFVKNID
QVSSEVLEGWPDSYKCDYPESYRGTLLKDFHMSELSCNITLLIVTIVATMLVLAVTVTSL
CSYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLE
KEGMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFH
EGSNSLILILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAINIKL
TEQAKK
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  Blast E-value cutoff:
BDBM50600882
n/a
NameBDBM50600882
Synonyms:CHEMBL5180856
TypeSmall organic molecule
Emp. Form.C64H76Cl3N7O10
Mol. Mass.1209.688
SMILESClC(Cl)(Cl)COC(=O)NCC(=O)OCCCCCCCCCCCCNC(=O)[C@@H]1CN(C[C@H]1C(=O)N[C@H]1C[C@@H]1c1ccccc1)C(=O)c1ccc(cc1)C(=O)N1C[C@H]([C@@H](C1)C(=O)N[C@H]1C[C@@H]1c1ccccc1)C(=O)N[C@H]1C[C@@H]1c1ccccc1 |r|
Structure
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