| Reaction Details |
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 | Report a problem with these data |
| Target | Glutaminyl-peptide cyclotransferase-like protein |
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| Ligand | BDBM50601352 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2236132 (CHEMBL5149904) |
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| IC50 | 359±n/a nM |
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| Citation |  Park, E; Song, KH; Kim, D; Lee, M; Van Manh, N; Kim, H; Hong, KB; Lee, J; Song, JY; Kang, S 2-Amino-1,3,4-thiadiazoles as Glutaminyl Cyclases Inhibitors Increase Phagocytosis through Modification of CD47-SIRP? Checkpoint. ACS Med Chem Lett13:1459-1467 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutaminyl-peptide cyclotransferase-like protein |
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| Name: | Glutaminyl-peptide cyclotransferase-like protein |
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| Synonyms: | Glutaminyl Cyclase | Glutaminyl-peptide cyclotransferase-like protein (QC) | QPCTL | QPCTL_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 42941.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NXS2 |
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| Residue: | 382 |
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| Sequence: | MRSGGRGRPRLRLGERGLMEPLLPPKRRLLPRVRLLPLLLALAVGSAFYTIWSGWHRRTE
ELPLGRELRVPLIGSLPEARLRRVVGQLDPQRLWSTYLRPLLVVRTPGSPGNLQVRKFLE
ATLRSLTAGWHVELDPFTASTPLGPVDFGNVVATLDPRAARHLTLACHYDSKLFPPGSTP
FVGATDSAVPCALLLELAQALDLELSRAKKQAAPVTLQLLFLDGEEALKEWGPKDSLYGS
RHLAQLMESIPHSPGPTRIQAIELFMLLDLLGAPNPTFYSHFPRTVRWFHRLRSIEKRLH
RLNLLQSHPQEVMYFQPGEPFGSVEDDHIPFLRRGVPVLHLISTPFPAVWHTPADTEVNL
HPPTVHNLCRILAVFLAEYLGL
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| BDBM50601352 |
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| n/a |
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| Name | BDBM50601352 |
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| Synonyms: | CHEMBL5178150 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12F3N5S |
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| Mol. Mass. | 375.371 |
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| SMILES | Nc1nnc(s1)-c1ccc2n(Cc3ccc(cc3)C(F)(F)F)cnc2c1 |
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| Structure | 
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