| Reaction Details |
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 | Report a problem with these data |
| Target | B1 bradykinin receptor |
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| Ligand | BDBM50182224 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_344573 (CHEMBL866612) |
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| IC50 | 1200±n/a nM |
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| Citation |  Fotsch, C; Biddlecome, G; Biswas, K; Chen, JJ; D'Amico, DC; Groneberg, RD; Han, NB; Hsieh, FY; Kamassah, A; Kumar, G; Lester-Zeiner, D; Liu, Q; Mareska, DA; Riahi, BB; Wang, YJ; Yang, K; Zhan, J; Zhu, J; Johnson, E; Ng, G; Askew, BC A new class of bradykinin 1 receptor antagonists containing the piperidine acetic acid tetralin core. Bioorg Med Chem Lett16:2071-5 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| B1 bradykinin receptor |
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| Name: | B1 bradykinin receptor |
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| Synonyms: | B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 40508.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P46663 |
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| Residue: | 353 |
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| Sequence: | MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLL
VFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKAN
LFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQA
VPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRC
GGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFF
AFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
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| BDBM50182224 |
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| n/a |
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| Name | BDBM50182224 |
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| Synonyms: | 2-((S)-1-(4-butoxyphenylsulfonyl)piperidin-2-yl)-N-((R)-6-((tert-butylamino)methyl)-1,2,3,4-tetrahydronaphthalen-1-yl)acetamide | CHEMBL426130 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H47N3O4S |
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| Mol. Mass. | 569.798 |
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| SMILES | CCCCOc1ccc(cc1)S(=O)(=O)N1CCCC[C@H]1CC(=O)N[C@@H]1CCCc2cc(CNC(C)(C)C)ccc12 |
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| Structure | 
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