| Reaction Details |
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 | Report a problem with these data |
| Target | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
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| Ligand | BDBM50602402 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2240293 (CHEMBL5154189) |
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| EC50 | >10000±n/a nM |
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| Citation |  Meibom, D; Micus, S; Andreevski, AL; Anlauf, S; Bogner, P; von Buehler, CJ; Dieskau, AP; Dreher, J; Eitner, F; Fliegner, D; Follmann, M; Gericke, KM; Maassen, S; Meyer, J; Schlemmer, KH; Steuber, H; Tersteegen, A; Wunder, F BAY-7081: A Potent, Selective, and Orally Bioavailable Cyanopyridone-Based PDE9A Inhibitor. J Med Chem65:16420-16431 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
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| Name: | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
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| Synonyms: | 3.1.4.35 | PDE9A_MOUSE | Pde8b | Pde9a |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61629.34 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_120641 |
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| Residue: | 534 |
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| Sequence: | MGAGSSSYRPKAIYLDIDGRIQKVVFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM
VSIDPTMPANSERTPYKVRPVAVKQVSEREELIQGVLAQVAEQFSRAFKINELKAEVANH
LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARNSRTNCPCKYSFLDNKKLTPRRDVP
TYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPITLRRWLLC
VHDNYRNNPFHNFRHCFCVTQMMYSMVWLCGLQEKFSQMDILVLMTAAICHDLDHPGYNN
TYQINARTELAVRYNDISPLENHHCAIAFQILARPECNIFASVPPEGFRQIRQGMITLIL
ATDMARHAEIMDSFKEKMENFDYSNEEHLTLLKMILIKCCDISNEVRPMEVAEPWVDCLL
EEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPVVEETMLR
PLWESREHYEELKQLDDAMKELQKKTESLTSGAPENTTEKNRDAKDSEGHSPPN
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| BDBM50602402 |
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| n/a |
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| Name | BDBM50602402 |
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| Synonyms: | CHEMBL5181099 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H27F3N4O4 |
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| Mol. Mass. | 456.4587 |
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| SMILES | OC(=O)C(F)(F)F.CCCC1CNCc2c1[nH]c(=O)c(C#N)c2N1CCC2(COC2)CC1 |
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| Structure | 
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