Reaction Details |
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Target | Melanin-concentrating hormone receptor 1 |
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Ligand | BDBM50186800 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_376788 (CHEMBL867266) |
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Ki | 26.0±n/a nM |
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Citation | Wu, WL; Burnett, DA; Spring, R; Qiang, L; Sasikumar, TK; Domalski, MS; Greenlee, WJ; O'Neill, K; Hawes, BE Synthesis and structure-activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists. Bioorg Med Chem Lett16:3668-73 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Melanin-concentrating hormone receptor 1 |
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Name: | Melanin-concentrating hormone receptor 1 |
Synonyms: | G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 45976.27 |
Organism: | Homo sapiens (Human) |
Description: | Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays. |
Residue: | 422 |
Sequence: | MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARL
WEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTIC
LLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHF
GETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALS
FISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRI
LQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVY
LYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESK
GT
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BDBM50186800 |
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n/a |
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Name | BDBM50186800 |
Synonyms: | 4'-[1-(1-benzyl-piperidin-4-yl)-3-(4,6-dichloro-1H-benzoimidazol-2-yl)-propyl]-biphenyl-3-carbonitrile | 4'-[1-(1-benzyl-piperidin-4-yl)-3-(5,7-dichloro-1H-benzoimidazol-2-yl)-propyl]-biphenyl-3-carbonitrile | CHEMBL377874 |
Type | Small organic molecule |
Emp. Form. | C35H32Cl2N4 |
Mol. Mass. | 579.561 |
SMILES | Clc1cc(Cl)c2[nH]c(CCC(C3CCN(Cc4ccccc4)CC3)c3ccc(cc3)-c3cccc(c3)C#N)nc2c1 |
Structure |
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