Reaction Details | |||
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Target | Melanin-concentrating hormone receptor 1 | ||
Ligand | BDBM50186858 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_376573 (CHEMBL866622) | ||
Ki | 64±n/a nM | ||
Citation | Wu, WL; Burnett, DA; Caplen, MA; Domalski, MS; Bennett, C; Greenlee, WJ; Hawes, BE; O'Neill, K; Weig, B; Weston, D; Spar, B; Kowalski, T Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists. Bioorg Med Chem Lett16:3674-8 (2006) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Melanin-concentrating hormone receptor 1 | |||
Name: | Melanin-concentrating hormone receptor 1 | ||
Synonyms: | G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 45976.27 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays. | ||
Residue: | 422 | ||
Sequence: |
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BDBM50186858 | |||
n/a | |||
Name | BDBM50186858 | ||
Synonyms: | 4-[(3'-cyano-biphenyl-4-yl)-(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-methylene]-piperidine-1-sulfonic acid dimethylamide | CHEMBL212573 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H25F4N5O2S | ||
Mol. Mass. | 583.6 | ||
SMILES | CN(C)S(=O)(=O)N1CCC(CC1)=C(c1nc2cc(c(F)cc2[nH]1)C(F)(F)F)c1ccc(cc1)-c1cccc(c1)C#N |(19.91,-30.21,;21.24,-29.43,;22.57,-30.2,;21.24,-27.89,;22.77,-27.89,;19.69,-27.89,;21.24,-26.35,;19.91,-25.58,;19.91,-24.05,;21.25,-23.28,;22.58,-24.04,;22.58,-25.58,;21.25,-21.74,;22.58,-20.97,;23.99,-21.6,;25.01,-20.45,;26.54,-20.45,;27.31,-19.12,;26.54,-17.79,;27.3,-16.46,;25.01,-17.79,;24.24,-19.12,;22.74,-19.44,;28.85,-19.13,;30.39,-19.12,;28.85,-20.67,;28.85,-17.59,;19.91,-20.98,;18.57,-21.75,;17.24,-20.98,;17.24,-19.43,;18.57,-18.66,;19.91,-19.43,;15.91,-18.66,;14.59,-19.43,;13.25,-18.67,;13.25,-17.12,;14.58,-16.35,;15.91,-17.12,;14.57,-14.81,;14.57,-13.27,)| | ||
Structure |