| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Stimulator of interferon genes protein |
|---|
| Ligand | BDBM50605474 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2251793 (CHEMBL5166003) |
|---|
| IC50 | 76±n/a nM |
|---|
| Citation |  Liu, J; Yuan, L; Ruan, Y; Deng, B; Yang, Z; Ren, Y; Li, L; Liu, T; Zhao, H; Mai, R; Chen, J Novel CRBN-Recruiting Proteolysis-Targeting Chimeras as Degraders of Stimulator of Interferon Genes with In Vivo Anti-Inflammatory Efficacy. J Med Chem65:6593-6611 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Stimulator of interferon genes protein |
|---|
| Name: | Stimulator of interferon genes protein |
|---|
| Synonyms: | ERIS | Endoplasmic reticulum interferon stimulator | MITA | Mediator of IRF3 activation | STING | STING1 | STING_HUMAN | Synonyms=ERIS | TMEM173 | Transmembrane protein 173 | hMITA | hSTING |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 42195.64 |
|---|
| Organism: | Human |
|---|
| Description: | Q86WV6 |
|---|
| Residue: | 379 |
|---|
| Sequence: | MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLL
NGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWM
LALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIR
TYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVY
SNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILA
DAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQE
PELLISGMEKPLPLRTDFS
|
|
|
|---|
| BDBM50605474 |
|---|
| n/a |
|---|
| Name | BDBM50605474 |
|---|
| Synonyms: | CHEMBL5189857 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H19FN2O4S |
|---|
| Mol. Mass. | 462.493 |
|---|
| SMILES | Oc1ccc(NC(=O)c2ccc(cc2)-c2ccccc2)cc1NS(=O)(=O)c1ccc(F)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
