| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-C |
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| Ligand | BDBM50605729 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2252775 (CHEMBL5166985) |
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| IC50 | 80±n/a nM |
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| Citation |  Yan, Y; Xing, C; Xiao, Y; Shen, X; Zhang, Z; He, C; Shi, JB; Liu, M; Liu, X Discovery and Anti-Inflammatory Activity Evaluation of a Novel CDK8 Inhibitor through Upregulation of IL-10 for the Treatment of Inflammatory Bowel Disease J Med Chem65:7334-7362 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-C |
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| Name: | Cyclin-C |
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| Synonyms: | CCNC | CCNC_HUMAN | Cyclin C | SRB11 homolog | hSRB11 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 33244.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107900 |
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| Residue: | 283 |
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| Sequence: | MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQ
VIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRF
SYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIV
NDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQ
WKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
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| BDBM50605729 |
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| n/a |
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| Name | BDBM50605729 |
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| Synonyms: | CHEMBL5182399 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H22N4O2 |
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| Mol. Mass. | 386.4464 |
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| SMILES | O=C(Nc1ccccc1)c1ccnc(c1)-c1ccc(cc1)C(=O)N1CCNCC1 |
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| Structure | 
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