Reaction Details |
| Report a problem with these data |
Target | Alpha-ketoglutarate-dependent dioxygenase FTO |
---|
Ligand | BDBM50328019 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2261090 (CHEMBL5216101) |
---|
IC50 | 15000±n/a nM |
---|
Citation | Shishodia, S; Demetriades, M; Zhang, D; Tam, NY; Maheswaran, P; Clunie-O'Connor, C; Tumber, A; Leung, IKH; Ng, YM; Leissing, TM; El-Sagheer, AH; Salah, E; Brown, T; Aik, WS; McDonough, MA; Schofield, CJ Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors. J Med Chem64:16609-16625 (2021) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Alpha-ketoglutarate-dependent dioxygenase FTO |
---|
Name: | Alpha-ketoglutarate-dependent dioxygenase FTO |
Synonyms: | FTO | FTO_HUMAN | Fat mass and obesity-associated protein | KIAA1752 |
Type: | PROTEIN |
Mol. Mass.: | 58263.75 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1515854 |
Residue: | 505 |
Sequence: | MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEE
LHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPV
KGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVG
MGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRS
AVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDD
LNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFE
PAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHE
VKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDD
ASMPLPFDLTDIVSELRGQLLEAKP
|
|
|
BDBM50328019 |
---|
n/a |
---|
Name | BDBM50328019 |
Synonyms: | 2-(3-hydroxypicolinamido)acetic acid | CHEMBL1256568 |
Type | Small organic molecule |
Emp. Form. | C8H8N2O4 |
Mol. Mass. | 196.1601 |
SMILES | OC(=O)CNC(=O)c1ncccc1O |
Structure |
|