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TargetTarget of rapamycin complex 2 subunit MAPKAP1
LigandBDBM50606764
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2261216 (CHEMBL5216227)
IC50<32±n/a nM
Citation Oleksak, P; Nepovimova, E; Chrienova, Z; Musilek, K; Patocka, J; Kuca, K Contemporary mTOR inhibitor scaffolds to diseases breakdown: A patent review (2015-2021). Eur J Med Chem238:0 (2022) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Target of rapamycin complex 2 subunit MAPKAP1
Name:Target of rapamycin complex 2 subunit MAPKAP1
Synonyms:MAPKAP1 | MIP1 | Mitogen-activated protein kinase 2-associated protein 1 | SAPK-interacting protein 1 | SIN1 | SIN1_HUMAN | Stress-activated map kinase-interacting protein 1 | TORC2 subunit MAPKAP1 | Target of rapamycin complex 2 subunit MAPKAP1 | mSIN1
Type:PROTEIN
Mol. Mass.:59129.70
Organism:Homo sapiens
Description:ChEMBL_119716
Residue:522
Sequence:
MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE
TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL
KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVY
LPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGE
VDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVT
MKEILLKAVKRRKGSQKVSGPQYRLEKQSEPNVAVDLDSTLESQSAWEFCLVRENSSRAD
GVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKAS
TKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVL
KVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50606764
n/a
NameBDBM50606764
Synonyms:CHEMBL5220568
TypeSmall organic molecule
Emp. Form.C96H144N12O22
Mol. Mass.1818.2378
SMILES[H][C@@]12CC[C@@H](C)[C@@](O)(O1)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@@]([H])(CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)C\C=C/C=C/C=C(C)/[C@H](C2)OC)[C@H](C)C[C@@H]1CC[C@@H](OCCCCc2cn(CCOCCOCCOCCOCCC(=O)NCCOCCOCCNC(=O)[C@H]3CC[C@@H](CC3)c3nc(-c4cc5cccc(OC)c5[nH]4)c4c(N)ncnn34)nn2)[C@@H](C1)OC |wU:1.0,59.61,128.139,56.59,18.20,22.24,34.36,39.41,4.4,6.6,102.108,wD:62.65,27.29,32.34,42.44,52.56,99.101,c:31,47,51,t:49,(-27.88,-14.45,;-29.37,-14.85,;-30.83,-15.36,;-31.91,-14.37,;-31.63,-12.87,;-32.81,-11.87,;-30.27,-12.35,;-31.36,-11.26,;-29.09,-13.35,;-30,-10.93,;-31.09,-9.95,;-28.55,-10.43,;-27.47,-11.41,;-28.28,-9.02,;-29.46,-8.02,;-29.18,-6.51,;-27.72,-6.01,;-26.64,-6.99,;-26.92,-8.5,;-25.44,-8.1,;-25.04,-6.61,;-24.35,-9.19,;-22.86,-8.79,;-21.37,-8.39,;-21.77,-9.88,;-20.28,-9.48,;-19.88,-7.99,;-19.25,-10.63,;-17.75,-10.31,;-19.73,-12.09,;-18.7,-13.24,;-17.2,-12.92,;-19.18,-14.7,;-20.69,-15.02,;-18.15,-15.85,;-16.65,-15.53,;-15.62,-16.68,;-17.57,-17.72,;-16.09,-18.12,;-18.56,-19.13,;-20.05,-18.73,;-18.16,-20.61,;-19.25,-21.7,;-18.85,-23.19,;-20.74,-21.3,;-21.83,-22.39,;-23.32,-21.99,;-23.71,-20.51,;-25.2,-20.11,;-25.6,-18.62,;-27.09,-18.22,;-28.18,-19.31,;-27.49,-16.73,;-28.97,-16.34,;-26.4,-15.65,;-26.8,-14.16,;-22.46,-7.3,;-20.97,-6.9,;-23.55,-6.21,;-23.15,-4.72,;-21.66,-4.33,;-21.26,-2.84,;-22.35,-1.75,;-21.95,-.26,;-20.47,.14,;-20.07,1.63,;-18.58,2.02,;-18.18,3.51,;-16.69,3.91,;-16.14,5.35,;-14.61,5.27,;-13.52,6.35,;-12.03,5.96,;-10.94,7.04,;-9.45,6.65,;-8.36,7.74,;-6.88,7.34,;-5.79,8.43,;-4.3,8.03,;-3.21,9.12,;-1.72,8.72,;-.64,9.81,;.85,9.41,;1.94,10.5,;3.43,10.1,;4.52,11.19,;4.12,12.67,;6,10.79,;7.09,11.88,;8.58,11.48,;9.67,12.57,;11.16,12.17,;12.25,13.26,;13.73,12.86,;14.82,13.95,;16.31,13.55,;17.4,14.64,;18.89,14.24,;19.28,12.75,;19.98,15.33,;21.46,14.93,;22.55,16.02,;22.15,17.51,;20.67,17.91,;19.58,16.82,;23.24,18.6,;24.76,18.35,;25.46,19.73,;26.95,20.12,;27.5,21.56,;29.04,21.48,;30.13,22.57,;31.61,22.17,;32.01,20.68,;30.92,19.6,;31.32,18.11,;32.81,17.71,;29.44,19.99,;28.14,19.16,;24.37,20.81,;24.45,22.35,;25.79,23.12,;23.16,23.19,;21.79,22.49,;21.71,20.95,;23,20.12,;-14.21,3.78,;-15.5,2.94,;-23.84,-2.15,;-24.24,-3.64,;-24.93,-1.06,;-26.42,-1.46,)|
Structure
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