| Reaction Details |
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 | Report a problem with these data |
| Target | Target of rapamycin complex 2 subunit MAPKAP1 |
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| Ligand | BDBM50606765 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2261216 (CHEMBL5216227) |
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| IC50 | <32±n/a nM |
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| Citation |  Oleksak, P; Nepovimova, E; Chrienova, Z; Musilek, K; Patocka, J; Kuca, K Contemporary mTOR inhibitor scaffolds to diseases breakdown: A patent review (2015-2021). Eur J Med Chem238:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Target of rapamycin complex 2 subunit MAPKAP1 |
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| Name: | Target of rapamycin complex 2 subunit MAPKAP1 |
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| Synonyms: | MAPKAP1 | MIP1 | Mitogen-activated protein kinase 2-associated protein 1 | SAPK-interacting protein 1 | SIN1 | SIN1_HUMAN | Stress-activated map kinase-interacting protein 1 | TORC2 subunit MAPKAP1 | Target of rapamycin complex 2 subunit MAPKAP1 | mSIN1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59129.70 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_119716 |
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| Residue: | 522 |
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| Sequence: | MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE
TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL
KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVY
LPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGE
VDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVT
MKEILLKAVKRRKGSQKVSGPQYRLEKQSEPNVAVDLDSTLESQSAWEFCLVRENSSRAD
GVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKAS
TKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVL
KVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ
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| BDBM50606765 |
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| n/a |
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| Name | BDBM50606765 |
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| Synonyms: | CHEMBL5219300 |
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| Type | Small organic molecule |
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| Emp. Form. | C89H124N20O17 |
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| Mol. Mass. | 1746.0607 |
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| SMILES | [H][C@@]12CC[C@@H](C)[C@@](O)(O1)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@@]([H])(C[C@@H](O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)\C(=N/OCc1cn(nn1)-c1cnc(nc1)N1CCN(CC1)c1ncc(cn1)C(=O)NCCOCCC(=O)NCCCCn1nc(-c3ccc4oc(N)nc4c3)c3c(N)ncnc13)[C@H](C)C[C@H](C)C\C=C/C=C/C=C(C)/[C@H](C2)OC)[C@H](C)C[C@@H]1CC[C@@H](O)[C@@H](C1)OC |c:31,115,119,t:117| |
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| Structure | 
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