| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Retinal dehydrogenase 2 |
|---|
| Ligand | BDBM50406341 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2266498 |
|---|
| IC50 | 1000±n/a nM |
|---|
| Citation |  Kargbo, RB Discovery of Selective Aldehyde Dehydrogenase Inhibitors for the Treatment of Cancer. ACS Med Chem Lett14:131-132 (2023) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Retinal dehydrogenase 2 |
|---|
| Name: | Retinal dehydrogenase 2 |
|---|
| Synonyms: | AL1A2_HUMAN | ALDH1A2 | Aldehyde dehydrogenase family 1 member A2 | RALDH 2 | RALDH(II) | RALDH2 | Retinal dehydrogenase 2 | Retinaldehyde-specific dehydrogenase type 2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 56720.77 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_109700 |
|---|
| Residue: | 518 |
|---|
| Sequence: | MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP
ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL
ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC
GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILP
GYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADAD
LDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQG
PQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG
PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ
SPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS
|
|
|
|---|
| BDBM50406341 |
|---|
| n/a |
|---|
| Name | BDBM50406341 |
|---|
| Synonyms: | CHEMBL5291299 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H14FN3O2S |
|---|
| Mol. Mass. | 367.397 |
|---|
| SMILES | Fc1ccccc1-c1ncsc1C(=O)Nc1ccc2NC(=O)CCc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
