| Reaction Details |
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 | Report a problem with these data |
| Target | Acid-sensing ion channel 1 |
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| Ligand | BDBM50408495 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2267837 |
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| IC50 | 2590±n/a nM |
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| Citation |  Gornati, D; Ciccone, R; Vinciguerra, A; Ippati, S; Pannaccione, A; Petrozziello, T; Pizzi, E; Hassan, A; Colombo, E; Barbini, S; Milani, M; Caccavone, C; Randazzo, P; Muzio, L; Annunziato, L; Menegon, A; Secondo, A; Mastrangelo, E; Pignataro, G; Seneci, P Synthesis and Characterization of Novel Mono- and Bis-Guanyl Hydrazones as Potent and Selective ASIC1 Inhibitors Able to Reduce Brain Ischemic Insult. J Med Chem64:8333-8353 (2021) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Acid-sensing ion channel 1 |
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| Name: | Acid-sensing ion channel 1 |
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| Synonyms: | ACCN2 | ASIC1 | ASIC1_HUMAN | Acid-sensing ion channel 1 | Amiloride-sensitive cation channel 2, neuronal | BNAC2 | Brain sodium channel 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59900.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1495930 |
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| Residue: | 528 |
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| Sequence: | MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV
CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN
RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS
AEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETS
FEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLD
FFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEY
CVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETI
EQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSA
DKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
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| BDBM50408495 |
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| n/a |
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| Name | BDBM50408495 |
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| Synonyms: | CHEMBL5267130 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H16F4N6O2 |
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| Mol. Mass. | 436.363 |
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| SMILES | OC(=O)C(F)(F)F.NC(=N)N\N=C\c1ccc(cc1)-c1cc(n[nH]1)-c1ccc(F)cc1 |
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| Structure | 
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