| Reaction Details |
|---|
 | Report a problem with these data |
| Target | NAD-dependent protein deacylase sirtuin-6 |
|---|
| Ligand | BDBM27507 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2268129 |
|---|
| IC50 | 184000±n/a nM |
|---|
| Citation |  Fiorentino, F; Mai, A; Rotili, D Emerging Therapeutic Potential of SIRT6 Modulators. J Med Chem64:9732-9758 (2021) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| NAD-dependent protein deacylase sirtuin-6 |
|---|
| Name: | NAD-dependent protein deacylase sirtuin-6 |
|---|
| Synonyms: | NAD-dependent protein deacetylase sirtuin-6 | NAD-dependent protein deacetylase sirtuin-6 (SIRT6) | Regulatory protein SIR2 homolog 6 | SIR2-like protein 6 | SIR2L6 | SIR6_HUMAN | SIRT6 | Sirtuin-6 (SIRT6) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 39133.03 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q8N6T7 |
|---|
| Residue: | 355 |
|---|
| Sequence: | MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASG
IPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHV
RSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGE
LRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVN
LQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPK
EESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS
|
|
|
|---|
| BDBM27507 |
|---|
| n/a |
|---|
| Name | BDBM27507 |
|---|
| Synonyms: | 3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacinamide | nicotinamide | pyridine-3-carboxamide |
|---|
| Type | n/a |
|---|
| Emp. Form. | C6H6N2O |
|---|
| Mol. Mass. | 122.1246 |
|---|
| SMILES | NC(=O)c1cccnc1 |
|---|
| Structure | 
|
|---|
Search and Browse
