Reaction Details |
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Target | Potassium voltage-gated channel subfamily A member 5 |
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Ligand | BDBM50194514 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_422064 (CHEMBL907690) |
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IC50 | 147±n/a nM |
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Citation | Nanda, KK; Nolt, MB; Cato, MJ; Kane, SA; Kiss, L; Spencer, RH; Wang, J; Lynch, JJ; Regan, CP; Stump, GL; Li, B; White, R; Yeh, S; Bogusky, MJ; Bilodeau, MT; Dinsmore, CJ; Lindsley, CW; Hartman, GD; Wolkenberg, SE; Trotter, BW Potent antagonists of the Kv1.5 potassium channel: synthesis and evaluation of analogous N,N-diisopropyl-2-(pyridine-3-yl)acetamides. Bioorg Med Chem Lett16:5897-901 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Potassium voltage-gated channel subfamily A member 5 |
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Name: | Potassium voltage-gated channel subfamily A member 5 |
Synonyms: | HK2 | HPCN1 | KCNA5 | KCNA5_HUMAN | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.5 |
Type: | Enzyme |
Mol. Mass.: | 67222.47 |
Organism: | Homo sapiens (Human) |
Description: | P22460 |
Residue: | 613 |
Sequence: | MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDA
DSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQ
RVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQ
SGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIF
EYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANG
SGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNII
DVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGL
QILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTT
VGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQG
TQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSL
YALCLDTSRETDL
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BDBM50194514 |
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n/a |
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Name | BDBM50194514 |
Synonyms: | CHEMBL217921 | methyl 4-(3-bromophenyl)-5-(diisopropylamino)-5-oxo-3-(pyridin-3-yl)pentanoate |
Type | Small organic molecule |
Emp. Form. | C23H29BrN2O3 |
Mol. Mass. | 461.392 |
SMILES | COC(=O)CC(C(C(=O)N(C(C)C)C(C)C)c1cccc(Br)c1)c1cccnc1 |
Structure |
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