| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50536188 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2274301 |
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| IC50 | 366±n/a nM |
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| Citation |  He, J; Qiao, W; An, Q; Yang, T; Luo, Y Dihydrofolate reductase inhibitors for use as antimicrobial agents. Eur J Med Chem195:0 (2020) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | Bacterial dihydrofolate reductase | DYR_ECOLI | Dihydrofolate Reductase (DHFR) | Tetrahydrofolate dehydrogenase | folA | tmrA |
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| Type: | Enzyme |
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| Mol. Mass.: | 17991.61 |
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| Organism: | Escherichia coli |
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| Description: | E. coli DHFR was expressed in BL21, and purified to homogeneity. |
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| Residue: | 159 |
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| Sequence: | MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI
ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE
GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
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| BDBM50536188 |
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| n/a |
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| Name | BDBM50536188 |
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| Synonyms: | CHEMBL4532935 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H21N5O2 |
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| Mol. Mass. | 387.4344 |
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| SMILES | CCc1nc(N)nc(N)c1C#CC(C)c1cc2OCOc2c(c1)-c1ccncc1 |
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| Structure | 
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