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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bile acid receptor | ||
| Ligand | BDBM50535382 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2276117 | ||
| EC50 | 1400±n/a nM | ||
| Citation |  Fang, Y; Hegazy, L; Finck, BN; Elgendy, B Recent Advances in the Medicinal Chemistry of Farnesoid X Receptor. J Med Chem64:17545-17571 (2021) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bile acid receptor | |||
| Name: | Bile acid receptor | ||
| Synonyms: | BAR | Bile acid receptor FXR | FXR | Farnesol receptor HRR-1 | HRR1 | NR1H4 | NR1H4_HUMAN | Nuclear receptor subfamily 1 group H member 4 | RIP14 | RXR-interacting protein 14 | Retinoid X receptor-interacting protein 14 | farnesoid x receptor | ||
| Type: | Nuclear Receptor | ||
| Mol. Mass.: | 55916.24 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q96RI1 | ||
| Residue: | 486 | ||
| Sequence: |
| ||
| BDBM50535382 | |||
| n/a | |||
| Name | BDBM50535382 | ||
| Synonyms: | CHEMBL4588863 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H23Cl2NO5 | ||
| Mol. Mass. | 512.381 | ||
| SMILES | CC(C)c1onc(c1COc1ccc(COc2cccc(c2)C(O)=O)cc1)-c1c(Cl)cccc1Cl |(56.53,-18.8,;54.99,-18.64,;54.36,-17.24,;54.09,-19.89,;52.55,-19.9,;52.08,-21.36,;53.34,-22.27,;54.57,-21.36,;56.04,-21.82,;57.18,-20.79,;58.64,-21.26,;58.97,-22.76,;60.43,-23.22,;61.57,-22.19,;63.04,-22.65,;64.18,-21.61,;65.65,-22.08,;65.97,-23.58,;67.44,-24.05,;68.57,-23.01,;68.24,-21.5,;66.77,-21.04,;69.37,-20.46,;70.84,-20.92,;69.04,-18.95,;61.24,-20.68,;59.77,-20.22,;53.34,-23.81,;54.68,-24.57,;56.01,-23.8,;54.68,-26.12,;53.35,-26.89,;52.01,-26.12,;52.02,-24.58,;50.68,-23.81,)| | ||
| Structure | 
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