| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PAK 1 |
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| Ligand | BDBM50609599 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2278549 |
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| IC50 | 233±n/a nM |
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| Citation |  Chow, HY; Karchugina, S; Groendyke, BJ; Toenjes, S; Hatcher, J; Donovan, KA; Fischer, ES; Abalakov, G; Faezov, B; Dunbrack, R; Gray, NS; Chernoff, J Development and Utility of a PAK1-Selective Degrader. J Med Chem65:15627-15641 (2022) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase PAK 1 |
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| Name: | Serine/threonine-protein kinase PAK 1 |
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| Synonyms: | 2.7.11.1 | Alpha-PAK | Cell division control protein 42 homolog | PAK 1/CDC42 | PAK-1 | PAK1 | PAK1_HUMAN | Serine/threonine-protein kinase PAK 1/PAK 2/PAK 3 | p21-activated kinase 1 | p65-PAK |
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| Type: | n/a |
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| Mol. Mass.: | 60640.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13153 |
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| Residue: | 545 |
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| Sequence: | MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILP
GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKN
PQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDD
DDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTE
KQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQ
MNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC
MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK
RSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNG
TPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEA
TKNNH
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| BDBM50609599 |
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| n/a |
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| Name | BDBM50609599 |
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| Synonyms: | CHEMBL5281068 |
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| Type | Small organic molecule |
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| Emp. Form. | C42H46ClF3N8O5 |
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| Mol. Mass. | 835.313 |
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| SMILES | CN1C(=O)CCC(N2C(=O)c3cccc(NCCCCCCCCNC(=O)N4CC[C@@H](C4)NC4=Nc5cc(F)ccc5N(CC(F)F)c5ccc(Cl)cc45)c3C2=O)C1=O |r,t:34| |
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| Structure | 
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