Reaction Details |
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Target | Programmed cell death 1 ligand 1 |
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Ligand | BDBM36335 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2281190 |
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IC50 | <100±n/a nM |
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Citation | Zhang, J; Zhang, Y; Qu, B; Yang, H; Hu, S; Dong, X If small molecules immunotherapy comes, can the prime be far behind? Eur J Med Chem218:0 (2021) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Programmed cell death 1 ligand 1 |
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Name: | Programmed cell death 1 ligand 1 |
Synonyms: | B7 homolog 1 | B7-H1 | B7H1 | B7H1 | CD274 | CD_antigen=CD274 | PD-L1 | PD1L1_HUMAN | PDCD1 ligand 1 | PDCD1L1 | PDCD1LG1 | PDL1 | Programmed cell death 1 ligand 1 | Programmed death ligand 1 |
Type: | PROTEIN |
Mol. Mass.: | 33278.49 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_109807 |
Residue: | 290 |
Sequence: | MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEME
DKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGG
ADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTT
TTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTH
LVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
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BDBM36335 |
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n/a |
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Name | BDBM36335 |
Synonyms: | US10639284, Compound 1.001 | US11426364, Compound 1.001 |
Type | Small organic molecule |
Emp. Form. | C32H28ClN3O5 |
Mol. Mass. | 570.035 |
SMILES | OC[C@H](NCc1cc(Cl)c(OC2CCc3c2cccc3-c2ccccc2)cc1OCc1cncc(c1)C#N)C(O)=O |r| |
Structure |
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