| Reaction Details |
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 | Report a problem with these data |
| Target | RAC-gamma serine/threonine-protein kinase |
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| Ligand | BDBM50398379 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2282226 |
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| IC50 | 8.0±n/a nM |
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| Citation |  Wang, C; Zhang, Y; Wu, Y; Xing, D Developments of CRBN-based PROTACs as potential therapeutic agents. Eur J Med Chem225:0 (2021) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| RAC-gamma serine/threonine-protein kinase |
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| Name: | RAC-gamma serine/threonine-protein kinase |
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| Synonyms: | AKT3 | AKT3_HUMAN | PKB gamma | PKBG | Protein kinase Akt-3 | Protein kinase B (Akt 3) | Protein kinase B, gamma | RAC-PK-gamma | RAC-gamma serine/threonine-protein kinase | STK-2 | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55769.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 479 |
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| Sequence: | MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ
LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS
PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK
KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE
RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA
ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM
EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP
PFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
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| BDBM50398379 |
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| n/a |
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| Name | BDBM50398379 |
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| Synonyms: | CHEMBL2177390 | US10550114, Compound GDC-0068 | US20230286979, Positive control GDC-0068 | US20230321108, Positive control GDC-0068 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H32ClN5O2 |
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| Mol. Mass. | 457.996 |
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| SMILES | CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](O)C[C@@H](C)c12)c1ccc(Cl)cc1 |r| |
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| Structure | 
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