| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Yes |
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| Ligand | BDBM50611364 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2283235 |
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| IC50 | 2.3±n/a nM |
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| Citation |  Chen, X; Huang, Y; Xu, W; Cai, Y; Yang, Y 4-Aminopyrazolopyrimidine scaffold and its deformation in the design of tyrosine and serine/threonine kinase inhibitors in medicinal chemistry. RSC Med Chem13:1008-1028 (2022) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Yes |
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| Name: | Tyrosine-protein kinase Yes |
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| Synonyms: | Proto-oncogene c-Yes | VHL/Tyrosine-protein kinase Yes | YES | YES1 | YES_HUMAN | p61-yes |
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| Type: | Protein |
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| Mol. Mass.: | 60801.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07947 |
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| Residue: | 543 |
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| Sequence: | MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMT
PFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQI
INNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRG
IFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHY
TEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT
KVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFL
KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARL
IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNRE
VLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPG
ENL
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| BDBM50611364 |
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| n/a |
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| Name | BDBM50611364 |
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| Synonyms: | CHEMBL5280361 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H25N5O5S |
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| Mol. Mass. | 483.54 |
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| SMILES | C[C@@H]1[C@@H](COS(=O)(=O)C=C)O[C@H]([C@@H]1OCC#C)n1nc(-c2ccc(C)cc2)c2c(N)ncnc12 |r| |
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| Structure | 
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