Reaction Details |
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Target | tRNA (guanine-N(1)-)-methyltransferase |
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Ligand | BDBM50613264 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2291656 |
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IC50 | 2100±n/a nM |
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Citation | Wilkinson, AJ; Ooi, N; Finlayson, J; Lee, VE; Lyth, D; Maskew, KS; Newman, R; Orr, D; Ansell, K; Birchall, K; Canning, P; Coombs, P; Fusani, L; McIver, E; Pisco, J; Ireland, PM; Jenkins, C; Norville, IH; Southern, SJ; Cowan, R; Hall, G; Kettleborough, C; Savage, VJ; Cooper, IR Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors. Bioorg Med Chem Lett90:0 (2023) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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tRNA (guanine-N(1)-)-methyltransferase |
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Name: | tRNA (guanine-N(1)-)-methyltransferase |
Synonyms: | 2.1.1.228 | M1G-methyltransferase | tRNA (guanine-N(1)-)-methyltransferase | tRNA [GM37] methyltransferase | trmD |
Type: | PROTEIN |
Mol. Mass.: | 28417.50 |
Organism: | Escherichia coli (strain K12) |
Description: | ChEMBL_120942 |
Residue: | 255 |
Sequence: | MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGM
LMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDE
RVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPH
YTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEF
KTEHAQQQHKHDGMA
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BDBM50613264 |
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n/a |
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Name | BDBM50613264 |
Synonyms: | CHEMBL5283956 |
Type | Small organic molecule |
Emp. Form. | C15H17N3O |
Mol. Mass. | 255.315 |
SMILES | CC(C)(Nc1ccc(cn1)C(N)=O)c1ccccc1 |
Structure |
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