Ki Summary

Reaction Details

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Target

GTPase KRas

Ligand

BDBM50614264

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2296186

IC50

1.000000±n/a nM

Citation

Kargbo, RB Targeting the "Undruggable" Driver Protein, KRAS ACS Med Chem Lett14:365-366 (2023) [PubMed]

More Info.:

Get all data from this article, Assay Method

GTPase KRas

Name:

GTPase KRas

Synonyms:

Type:

PROTEIN

Mol. Mass.:

21656.10

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1476955

Residue:

189

Sequence:

MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM

BDBM50614264

n/a

Name

BDBM50614264

Synonyms:

CHEMBL5286301

Type

Small organic molecule

Emp. Form.

C35H39F2N5O3

Mol. Mass.

615.7127

SMILES

CCc1cccc2cc(O)cc(-c3ncc4c(nc(OC[C@@]56CCCN5C[C@H](F)C6)nc4c3F)N3CCCC4(CC(O)C4)C3)c12 |r,wU:27.28,wD:21.20,(-4.59,2.41,;-4.59,.87,;-5.92,.1,;-7.26,.85,;-8.58,.07,;-8.57,-1.47,;-7.24,-2.23,;-7.24,-3.76,;-5.9,-4.53,;-5.9,-6.07,;-4.57,-3.76,;-4.57,-2.22,;-3.24,-1.45,;-3.24,.09,;-1.9,.86,;-.57,.1,;.76,.86,;2.09,.09,;2.09,-1.44,;3.43,-2.21,;4.76,-1.44,;6.14,-2.12,;5.09,-3.23,;5.8,-4.6,;7.28,-4.35,;7.52,-2.8,;8.58,-1.69,;7.87,-.32,;8.55,1.07,;6.38,-.57,;.77,-2.22,;-.57,-1.44,;-1.9,-2.21,;-1.9,-3.75,;.76,2.4,;-.58,3.17,;-.58,4.71,;.76,5.48,;2.09,4.71,;3.42,3.94,;4.21,5.3,;5.69,5.7,;2.87,6.07,;2.09,3.17,;-5.91,-1.45,)|

Structure