| Reaction Details |
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 | Report a problem with these data |
| Target | GTPase KRas |
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| Ligand | BDBM50614266 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2296187 |
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| IC50 | 3.0±n/a nM |
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| Citation |  Kargbo, RB Targeting the "Undruggable" Driver Protein, KRAS ACS Med Chem Lett14:365-366 (2023) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| GTPase KRas |
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| Name: | GTPase KRas |
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| Synonyms: | GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras |
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| Type: | PROTEIN |
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| Mol. Mass.: | 21656.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1476955 |
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| Residue: | 189 |
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| Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
|
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|
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| BDBM50614266 |
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| n/a |
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| Name | BDBM50614266 |
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| Synonyms: | CHEMBL5279240 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H36F3N5O3 |
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| Mol. Mass. | 619.6765 |
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| SMILES | CCc1c(F)ccc2cc(O)cc(-c3ncc4c(nc(OC[C@@]56CCCN5C[C@H](F)C6)nc4c3F)N3CCCC4(CCO4)C3)c12 |r| |
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| Structure | 
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