| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-2A adrenergic receptor [16-465] |
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| Ligand | BDBM50201046 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_422965 (CHEMBL909867) |
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| Ki | >1000±n/a nM |
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| Citation |  Cesari, N; Biancalani, C; Vergelli, C; Dal Piaz, V; Graziano, A; Biagini, P; Ghelardini, C; Galeotti, N; Giovannoni, MP Arylpiperazinylalkylpyridazinones and analogues as potent and orally active antinociceptive agents: synthesis and studies on mechanism of action. J Med Chem49:7826-35 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-2A adrenergic receptor [16-465] |
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| Name: | Alpha-2A adrenergic receptor [16-465] |
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| Synonyms: | ADA2A_RAT | Adra2a | Adrenaline 2 | Alpha-2A adrenergic receptor | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | Alpha-2D adrenergic receptor | Alpha2 Adrenoreceptor | CA2-47 | adrenergic Alpha2A |
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| Type: | G-protein coupled receptor |
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| Mol. Mass.: | 48961.69 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P22909[16-465] |
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| Residue: | 450 |
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| Sequence: | MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFT
SRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSS
IVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGG
QQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACS
APPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSE
HAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKAS
RWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSS
LNPVIYTIFNHDFRRAFKKILCRGDRKRIV
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| BDBM50201046 |
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| n/a |
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| Name | BDBM50201046 |
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| Synonyms: | 5-{3-[4-(3-chlorophenyl)hexahydro-1-pyrazinyl]propyl}-3-methyl-7-phenyl-4,5-dihydroisoxazolo[4,5-d]pyridazin-4-one | 5-{[4-(3-chlorophenyl)piperazin-1-yl]propyl}-3-methyl-7-phenylisoxazolo[4,5-d]pyridazinon-4-(5H)-one | CHEMBL10161 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H26ClN5O2 |
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| Mol. Mass. | 463.959 |
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| SMILES | Cc1noc2c(nn(CCCN3CCN(CC3)c3cccc(Cl)c3)c(=O)c12)-c1ccccc1 |
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| Structure | 
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