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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50203598 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_454261 (CHEMBL903444) | ||
| Ki | 8.2±n/a nM | ||
| Citation |  Han, X; Civiello, R; Pin, SS; Burris, K; Balanda, LA; Knipe, J; Ren, S; Fiedler, T; Browman, KE; Macci, R; Taber, MT; Zhang, J; Dubowchik, GM An orally active corticotropin releasing factor 1 receptor antagonist from 8-aryl-1,3a,7,8-tetraaza-cyclopenta[a]indenes. Bioorg Med Chem Lett17:2026-30 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 415 | ||
| Sequence: |
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| BDBM50203598 | |||
| n/a | |||
| Name | BDBM50203598 | ||
| Synonyms: | CHEMBL397389 | cyclobutylmethyl-[2-methyl-8-(2,4,6-trimethyl-phenyl)-8H-1,3a,7,8-tetraaza-cyclopenta[a]inden-3-ylmethyl]-propyl-amine | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H35N5 | ||
| Mol. Mass. | 429.6003 | ||
| SMILES | CCCN(CC1CCC1)Cc1c(C)nc2n(-c3c(C)cc(C)cc3C)c3ncccc3n12 |(24.76,4.65,;23.25,4.38,;22.72,2.93,;21.2,2.66,;20.42,3.99,;18.88,3.97,;17.77,5.05,;16.7,3.94,;17.8,2.87,;20.68,1.22,;21.67,.04,;21.3,-1.46,;19.88,-2.04,;22.61,-2.27,;23.79,-1.28,;25.33,-1.17,;26.32,-2.35,;27.82,-2.08,;28.35,-.64,;28.81,-3.26,;28.29,-4.71,;29.28,-5.89,;26.77,-4.98,;25.78,-3.8,;24.27,-4.06,;25.7,.32,;27.07,1.04,;27.13,2.59,;25.81,3.41,;24.45,2.68,;24.39,1.14,;23.21,.15,)| | ||
| Structure | 
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