| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 5 |
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| Ligand | BDBM50205761 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_447183 (CHEMBL897483) |
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| IC50 | 580±n/a nM |
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| Citation |  Lu, SF; Chen, B; Davey, D; Dunning, L; Jaroch, S; May, K; Onuffer, J; Phillips, G; Subramanyam, B; Tseng, JL; Wei, RG; Wei, M; Ye, B CCR5 receptor antagonists: discovery and SAR of novel 4-hydroxypiperidine derivatives. Bioorg Med Chem Lett17:1883-7 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 5 |
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| Name: | C-C chemokine receptor type 5 |
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| Synonyms: | C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 40540.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51681 |
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| Residue: | 352 |
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| Sequence: | MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
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| BDBM50205761 |
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| n/a |
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| Name | BDBM50205761 |
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| Synonyms: | 1-(2-(4-chlorobenzyloxy)-5-bromobenzyl)-4-(trifluoromethyl)piperidin-4-ol | CHEMBL393004 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H20BrClF3NO2 |
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| Mol. Mass. | 478.731 |
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| SMILES | OC1(CCN(Cc2cc(Br)ccc2OCc2ccc(Cl)cc2)CC1)C(F)(F)F |
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| Structure | 
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