Ki Summary

Reaction Details

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Target

Alpha-1D adrenergic receptor

Ligand

BDBM50211334

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_444278 (CHEMBL894518)

5.1±n/a nM

Citation

Chiu, G; Li, S; Connolly, PJ; Pulito, V; Liu, J; Middleton, SA (Arylpiperazinyl)cyclohexylsufonamides: discovery of alpha(1a/1d)-selective adrenergic receptor antagonists for the treatment of Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms (BPH/LUTS). Bioorg Med Chem Lett17:3292-7 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Alpha-1D adrenergic receptor

Name:

Alpha-1D adrenergic receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

60485.82

Organism:

Homo sapiens (Human)

Description:

adrenergic Alpha1D ADRA1D HUMAN::P25100

Residue:

572

Sequence:

MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAG
SGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILS
VACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCC
TASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVP
PDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKAS
EVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLC
WFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQ
CRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEM
QAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVE
AVSLGVPHEVAEGATCQAYELADYSNLRETDI

BDBM50211334

n/a

Name

BDBM50211334

Synonyms:

CHEMBL236832 | N-((1s,4s)-4-(4-(2-isopropoxyphenyl)piperazin-1-yl)cyclohexyl)-2,5-dimethoxybenzenesulfonamide

Type

Small organic molecule

Emp. Form.

C27H39N3O5S

Mol. Mass.

517.681

SMILES

COc1ccc(OC)c(c1)S(=O)(=O)N[C@H]1CC[C@H](CC1)N1CCN(CC1)c1ccccc1OC(C)C |wU:17.21,14.14,(5.06,-2.44,;4.28,-3.8,;5.06,-5.16,;6.59,-5.16,;7.36,-6.49,;6.59,-7.81,;7.37,-9.16,;8.89,-9.16,;5.07,-7.81,;4.31,-6.47,;4.3,-9.14,;2.97,-8.38,;5.64,-9.92,;3.53,-10.47,;1.97,-10.47,;1.2,-11.8,;-.33,-11.8,;-1.1,-10.47,;-.33,-9.13,;1.2,-9.15,;-2.65,-10.47,;-3.42,-11.81,;-4.96,-11.81,;-5.74,-10.47,;-4.96,-9.15,;-3.41,-9.15,;-7.28,-10.47,;-8.06,-11.8,;-9.59,-11.8,;-10.36,-10.47,;-9.59,-9.13,;-8.05,-9.13,;-7.28,-7.79,;-8.05,-6.46,;-7.28,-5.12,;-9.6,-6.46,)|

Structure