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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Alpha-1A adrenergic receptor | ||
| Ligand | BDBM50211342 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_444276 (CHEMBL894516) | ||
| Ki | 4.5±n/a nM | ||
| Citation |  Chiu, G; Li, S; Connolly, PJ; Pulito, V; Liu, J; Middleton, SA (Arylpiperazinyl)cyclohexylsufonamides: discovery of alpha(1a/1d)-selective adrenergic receptor antagonists for the treatment of Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms (BPH/LUTS). Bioorg Med Chem Lett17:3292-7 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Alpha-1A adrenergic receptor | |||
| Name: | Alpha-1A adrenergic receptor | ||
| Synonyms: | ADA1A_HUMAN | ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha adrenergic receptor 1a | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C | ||
| Type: | Cell-surface receptors | ||
| Mol. Mass.: | 51511.67 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P35348 | ||
| Residue: | 466 | ||
| Sequence: |
| ||
| BDBM50211342 | |||
| n/a | |||
| Name | BDBM50211342 | ||
| Synonyms: | 2,4-dichloro-N-((1s,4s)-4-(4-(2-isopropoxyphenyl)piperazin-1-yl)cyclohexyl)benzenesulfonamide | CHEMBL391035 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H33Cl2N3O3S | ||
| Mol. Mass. | 526.519 | ||
| SMILES | CC(C)Oc1ccccc1N1CCN(CC1)[C@@H]1CC[C@@H](CC1)NS(=O)(=O)c1ccc(Cl)cc1Cl |wU:16.17,19.24,(-7.91,-40.14,;-8.67,-41.47,;-10.21,-41.47,;-7.91,-42.8,;-8.67,-44.13,;-10.21,-44.13,;-10.98,-45.46,;-10.21,-46.8,;-8.67,-46.8,;-7.91,-45.46,;-6.37,-45.46,;-5.6,-46.8,;-4.06,-46.8,;-3.29,-45.46,;-4.06,-44.13,;-5.6,-44.13,;-1.75,-45.46,;-.99,-46.8,;.55,-46.8,;1.32,-45.46,;.55,-44.13,;-.99,-44.13,;2.86,-45.46,;3.63,-44.13,;2.3,-43.37,;4.95,-44.91,;4.39,-42.8,;3.63,-41.47,;4.39,-40.14,;5.93,-40.14,;6.7,-38.81,;6.7,-41.47,;5.93,-42.8,;6.7,-44.13,)| | ||
| Structure | 
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