Reaction Details | |||
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Target | Alpha-1A adrenergic receptor | ||
Ligand | BDBM50211346 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_444276 (CHEMBL894516) | ||
Ki | 1.3±n/a nM | ||
Citation | Chiu, G; Li, S; Connolly, PJ; Pulito, V; Liu, J; Middleton, SA (Arylpiperazinyl)cyclohexylsufonamides: discovery of alpha(1a/1d)-selective adrenergic receptor antagonists for the treatment of Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms (BPH/LUTS). Bioorg Med Chem Lett17:3292-7 (2007) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Alpha-1A adrenergic receptor | |||
Name: | Alpha-1A adrenergic receptor | ||
Synonyms: | ADA1A_HUMAN | ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha adrenergic receptor 1a | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C | ||
Type: | Cell-surface receptors | ||
Mol. Mass.: | 51511.67 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P35348 | ||
Residue: | 466 | ||
Sequence: |
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BDBM50211346 | |||
n/a | |||
Name | BDBM50211346 | ||
Synonyms: | 4-fluoro-N-((1r,4r)-4-(4-(2-isopropoxyphenyl)piperazin-1-yl)cyclohexyl)benzenesulfonamide | CHEMBL428197 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H34FN3O3S | ||
Mol. Mass. | 475.619 | ||
SMILES | CC(C)Oc1ccccc1N1CCN(CC1)[C@H]1CC[C@@H](CC1)NS(=O)(=O)c1ccc(F)cc1 |wU:16.17,wD:19.24,(16.2,-15.13,;15.43,-16.47,;13.89,-16.47,;16.21,-17.8,;15.44,-19.13,;13.9,-19.14,;13.14,-20.48,;13.92,-21.81,;15.46,-21.8,;16.22,-20.47,;17.75,-20.46,;18.53,-21.79,;20.07,-21.78,;20.83,-20.45,;20.06,-19.12,;18.52,-19.13,;22.37,-20.44,;23.13,-19.11,;24.67,-19.11,;25.44,-20.44,;24.67,-21.77,;23.14,-21.78,;27,-20.45,;27.75,-19.11,;26.41,-18.35,;29.09,-19.85,;28.49,-17.75,;30.04,-17.72,;30.78,-16.37,;29.97,-15.05,;30.71,-13.7,;28.43,-15.1,;27.7,-16.45,)| | ||
Structure |